Islet Cell Transplant: Successful Survival Through two Pregnancies

ABSTRACT Objective: To review the clinical course of a woman who, after islet cell transplant, successfully carried 2 pregnancies to term. Methods: Clinical and laboratory data are presented. Results: This is the first report of a woman with type 1 diabetes mellitus who received an islet cell transplant and then successfully carried 2 pregnancies to term. Hemoglobin A1c levels were within the goal range for both pregnancies. Only the administration of basal insulin was required with each pregnancy. Basal insulin requirements increased from the first to second pregnancy (from 0.42 U/kg to 0.70 U/kg). There were no major congenital malformations, macrosomia, or neonatal hypoglycemia. Conclusion: Excellent glycemic control was maintained with basal insulin therapy during both pregnancies. The significance of the increased basal insulin requirements during the second pregnancy in regards to islet cell function and future islet cell viability is currently unknown. Abbreviations: DM1 type 1 diabetes mellitus HbA1c hemoglobin A1c