Acute Myeloid Leukemia Associated Leukocytic Hypophysitis Presenting with Central Diabetes Insipidus

ABSTRACT Objective: Central diabetes insipidus is a rare complication of acute myeloid leukemia and myelodysplastic syndrome. To date there are fewer than 100 cases reported in the literature, and no published case reports in the endocrinology literature. We report a case of myelodysplastic syndrome transformed to secondary acute myeloid leukemia that was complicated by central diabetes insipidus. Methods: We detail the course of a 65-year-old female who presented with central diabetes insipidus in the setting of acute myeloid leukemia. Results: The patient's central diabetes insipidus was successfully controlled with desmopressin. As her disease was treated, her central diabetes insipidus resolved. Conclusion: This case highlights an important association between acute myeloid leukemia, myelodysplastic syndrome, and central diabetes insipidus. To our knowledge, this is the first published case in the endocrinology literature of central diabetes insipidus secondary to acute myeloid leukemia. Abbreviations: AML = acute myeloid leukemia; CDI = central diabetes insipidus; dDAVP = desmopressin; MDS = myelodysplastic syndrome